Platelets / editor, Alan D. Michelson. - Second edition. - xlii, 1343 pages : illustrations (some colour) ; 29 cm

Previous ed.: 2002.

Includes bibliographical references and index.

Foreword : a brief history of ideas about platelets in health and disease / The evolution of mammalian platelets / Megakaryocyte development and platelet formation / Platelet structure / The platelet cytoskeleton / Platelet genomics and proteomics / Platelet receptors / The glycoprotein Ib-IX-V complex / Integrin [alpha]IIb[beta]3 / Thrombin receptors / The platelet P2 receptors / Pecam-1 / P-selectin/PSGL-1 and other interactions between platelets, leukocytes, and endothelium / Inhibition of platelet function by the endothelium / Platelet polymorphisms / Platelet secretion / Signal transduction during platelet plug formation / Outside-in signaling by integrin [alpha]IIb[beta]3 / Platelet thrombus formation in flowing blood / Interactions between platelets and the coagulation system / Platelet-derived microparticles / The role of platelets in fibrinolysis / Platelet function in the newborn / Clinical tests of platelet function / Platelet counting / The bleeding time / Platelet aggregation / The VerifyNow system / The platelet function analyzer (PFA)-100 / Impact cone and plate(let) analyzer / Flow cytometry / Thromboxane generation / Perfusion chambers / Animal models / Real-time in vivo imaging of platelets during thrombus formation / Atherothrombosis and coronary artery disease / Central nervous system ischemia / Peripheral vascular disease / Diabetes mellitus / Inflammation / Antimicrobial host defense / Angiogenesis / Tumor growth and metastasis / Alzheimer's disease / Psychiatric disorders / The clinical approach to disorders of platelet number and function / Immune thrombocytopenic purpura / HIV-1-related thrombocytopenia / Heparin-induced thrombocytopenia / Drug-induced thrombocytopenia / Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome / Thrombocytopenia in pregnancy / Thrombocytopenia in the newborn / Alloimmune thrombocytopenia / Inherited thrombocytopenias / Pseudothrombocytopenia / Thrombocytosis and essential thrombocythemia / Inherited disorders of platelet function / Acquired disorders of platelet function / Cardiopulmonary bypass / Aspirin / ADP receptor antagonists / [alpha]IIb[beta]3 (GPIIb-IIIa) antagonists / Dipyridamole / Cilostazol / Experimental antiplatelet therapy / Platelet growth factors / Desmopressin (DDAVP) / Factor VIIa / Platelet storage and transfusion / Platelet substitutes and novel methods of platelet preservation / Gene therapy for platelet disorders / Barry S. Coller -- Jack Levin -- Joseph E. Italiano, Jr. and John H. Hartwig -- James G. White -- John H. Hartwig -- Angel Garcia, Yotis Senis, Michael G. Tomlinson and Steve P. Watson -- Kenneth J. Clemetson and Jeannine M. Clemetson -- Robert K. Andrews, Michael C. Berndt and Jose A. Lopez -- Edward F. Plow, Michelle M. Pesho and Yan-Qing Ma -- Wadie F. Bahou -- Marco Cattaneo -- Melanie S. Novinska, Vipul Rathore, Debra K. Newman and Peter J. Newman -- Rodger P. McEver -- Sybille Rex and Jane E. Freedman -- Vahid Afshar-Kharghan, K. Vinod Vijayan and Paul F. Bray -- Guy L. Reed -- Lawrence F. Brass, Timothy J. Stalker, Li Zhu and Donna S. Woulfe -- Nicolas Prevost and Sanford J. Shattil -- Brian Savage and Zaverio M. Ruggeri -- Beth A. Bouchard, Saulius Butenas, Kenneth G. Mann and Paula B. Tracy -- Rienk Nieuwland and Augueste Sturk -- Bradley A. Maron and Joseph Loscalzo -- Sara J. Israels -- Paul Harrison and David Keeling -- Carol Briggs, Paul Harrison and Samuel J. Machin -- Stuart E. Lind and Carla D. Kurkjian -- Lisa K. Jennings and Melanie McCabe White -- Steven R. Steinhubl -- John L. Francis -- David Varon and Naphtali Savion -- Alan D. Michelson, Matthew D. Linden, Marc R. Barnard, Mark I. Furman and A. L. Frelinger III -- Tilo Grosser, Susanne Fries and Garret A. FitzGerald -- Philip G. de Groot and Jan J. Sixma -- David H. Lee and Morris A. Blajchman -- Christophe Dubois, Ben Atkinson, Barbara Furie and Bruce Furie -- Pascal J. Goldschmidt, Neuza Lopes, Lawrence E. Crawford and Richard C. Becker -- Gregory J. del Zoppo -- Michael Sobel -- Bernd Stratmann, Barbara Menart and Diethelm Tschoepe -- Wolfgang Bergmeier and Denisa D. Wagner -- Michael R. Yeaman and Arnold S. Bayer -- Alexander Brill and David Varon -- Mary Lynn Nierodzik and Simon Karpatkin -- Qiao-Xin Li and Colin L. Masters -- George N. M. Gurguis -- Alan D. Michelson -- James B. Bussel -- Michael A. Nardi, Zongdong Li and Simon Karpatkin -- Beng H. Chong -- Richard H. Aster -- Joel L. Moake -- Keith R. McCrae -- Irene A. G. Roberts and Neil A. Murray -- Cecile Kaplan and John Freedman -- Michele P. Lambert and Mortimer Poncz -- Nicola Bizzaro -- Ayalew Tefferi -- Alan T. Nurden and Paquita Nurden -- A. Koneti Rao -- Brian Richard Smith, Henry M. Rinder and Christine S. Rinder -- Eric H. Awtry and Joseph Loscalzo -- Marco Cattaneo -- Ramtin Agah, Edward F. Plow and Eric J. Topol -- Wolfgang G. Eisert -- Yasuo Ikeda, Toshiki Sudo and Yukio Kimura -- Anthony A. Bavry, Deepak L. Bhatt and Eric J. Topol -- David J. Kuter -- Pier Mannuccio Mannucci and Marco Cattaneo -- Man-Chiu Poon -- Peter L. Perrotta and Edward L. Snyder -- David H. Lee and Morris A. Blajchman -- David A. Wilcox and Gilbert C. White II. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71.

0123693675 9780123693679


Blood platelets.

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