Allergy, immunity and tolerance in early childhood : the first steps of the atopic march / [edited by] Ulrich Wahn, Hugh A. Sampson.

Includes bibliographical references and index.

Front Cover; Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March; Copyright; Contents; List of Contributors; Introduction; 1 -- The Maturation of Immune Function in Pregnancy and Early Childhood; Introduction; Immune development in health and disease; Early life immune regulation; Interplay of innate and adaptive immune regulation in organ-specific responses; Key influences and determinants of early immune function and regulation; Genetic factors; Direct effects of maternal allergy on immune maturation; Maternal environmental exposures and immune maturation

Early postnatal exposures and immune maturationModulating early immune development to promote immune regulation; Conclusion; References; 2 -- Immunological Aspects of the Atopic March; Introduction; Global inventory of the developmental pattern of allergen-specific antibody; Tentative interpretation of phases observed in the serological picture; The trends of IgE levels to allergenic sources; Immunoglobulin E trends examined at a molecular level; Discussion; References; 3 -- Atopic Dermatitis in Infancy and Childhood; Definition; Family history and genetics; Natural history of disease

Allergic sensitization and allergy as comorbidityRhinitis and asthma as comorbidity; Urticaria as comorbidity; Determinants of the disease; Socioeconomic status; Infant feeding; Domestic environment; Key elements of treatment; Prevention; Long-term outcome in adulthood; References; Further reading; 4 -- Adverse Reactions to Food; Clinical presentation of food allergy in infancy; Epidemiology and natural course; Pathogenesis; Diagnostic; Therapy; Immunotherapy for food allergy; References; Further reading; 5 -- Viral-Induced Wheeze and Asthma Development; Introduction

Longitudinal studies of childhood wheezingEtiology of wheezing illnesses in infancy; Risk factors for virus-induced wheezing; Progression from virus-induced wheezing to asthma; Do severe viral respiratory infections in infancy cause asthma?; Conclusions; References; 6 -- Infantile Lung Function and Airway Hyperresponsiveness; Introduction; Lung development; Lung function measurements; Lung function development; Postnatal impact on lung function development; Factors that may influence in utero lung function development; Infantile AHR; Summary and conclusion; References

7 -- The Development of Allergic Rhinitis in ChildhoodIncidence; Period prevalence; Sex differences; Comorbidity; The role of sensitization; Early predictors; Protective factors; Principles of therapy; Options for prevention; References; Further reading; 8 -- Genes and Atopic Phenotypes; Introduction; Tools for disentangling the genetics of atopy; Do genes co-associated with multiple childhood atopy phenotypes represent atopic march candidate genes?; Summary and conclusions; References; 9 -- Epigenetic Factors Before and After Birth; Introduction; Principles of epigenetic mechanisms

Machine converted from AACR2 source record.