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Transfusion & transplantation science / edited by Robin Knight.

Contributor(s): Material type: TextTextSeries: Fundamentals of biomedical sciencePublisher: Oxford : Oxford University Press, 2013Description: xiii, 290 pages : illustrations ; 25 cmContent type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
ISBN:
  • 0199533288
  • 9780199533282
Other title:
  • Transfusion and transplantation science
Subject(s): DDC classification:
  • 615.39 22
LOC classification:
  • RM
Contents:
1.Introduction to Basic Immunology and Techniques / Robin Knight -- Introduction -- 1.1.Basic immunology and techniques -- 1.2.Antibody structure -- 1.3.Antibody function -- 1.4.Antigen-antibody reactions -- 1.5.Antibody mediated red cell destruction -- 1.6.In vitro detection of antigen-antibody reactions -- 1.7.Techniques -- Chapter summary -- 2.Human Erythrocyte Antigens or Blood Groups / Malcolm Needs -- Introduction -- 2.1.The ABO, H, and Lewis blood group systems -- 2.2.The Lewis blood group system and secretor -- 2.3.The MNS blood group system -- 2.4.The Rh, RHAG, and LW blood group systems -- 2.5.The Lutheran blood group system -- 2.6.The Kell and Kx blood group systems -- 2.7.The Duffy blood group system -- 2.8.The Kidd blood group system -- 2.9.The PIPK blood group system -- 2.10.Other blood groups -- Chapter summary -- Further reading -- 3.Donors and Donation: Collection and Processing / Lionel Mohabir -- Introduction --
3.1.Blood donation -- 3.2.Donor/donation linking -- 3.3.Component preparation -- 3.4.Pathogen reduction -- 3.5.Component validation and labelling -- Chapter summary -- Further reading -- 4.Blood Donation Testing / Lionel Mohabir -- Introduction -- 4.1.Mandatory testing -- 4.2.Additional (discretionary) testing -- 4.3.Microbiology serology testing -- 4.4.Microbiology positive screen and confirmatory testing -- 4.5.Bacterial contamination -- 4.6.West Nile virus (WNV) -- 4.7.Other threats to the blood supply -- 4.8.Quality control/British working standards -- Chapter summary -- Further reading -- 5.Clinical Use of Blood Components / Bill Chaffe -- Introduction -- 5.1.Structure and function of blood -- 5.2.Normal physiological response to anaemia and/or bleeding -- 5.3.Blood components available and their appropriate use -- 5.4.Blood products -- 5.5.Special requirements -- 5.6.Decision making, who needs a transfusion, risks and benefits --
5.7.Alternatives to donor blood -- 5.8.Case history examples -- Chapter summary -- Further reading -- 6.Compatibility Testing and Adverse Effects / Tony Davies -- Introduction -- 6.1.Compatibility testing (serological and non-serological) -- 6.2.Selection of plasma products -- 6.3.Selection of cellular components -- 6.4.Visual inspection and labelling of the units -- 6.5.Traceability of blood components -- 6.6.Adverse effects of transfusion -- 6.7.Monitoring the patient during transfusion -- 6.8.Investigation of transfusion reactions -- 6.9.Haemovigilance in the UK -- Chapter summary -- Further reading -- 7.Immune Red Cell Destruction / Robin Knight -- Introduction -- 7.1.What is immune (antibody mediated) red cell destruction? -- 7.2.Clinical significance of red cell antibodies -- 7.3.Haemolytic transfusion reactions -- 7.4.Autoimmune haemolytic anaemias -- 7.5.Haemolysis post-transplantation bone marrow/stem cell transplant --
7.6.Haemolytic disease of the newborn or foetus (HDN) -- Chapter summary -- Further reading -- 8.Human Leucocyte Antigens and Their Clinical Significance / Colin Brown -- Introduction -- 8.1.A brief history of transplantation -- 8.2.Human leucocyte antigens -- 8.3.The detection and definition of human leucocyte antigens, alleles, and antibodies -- 8.4.Clinical significance of human leucocyte antigens in transplantation -- 8.5.Clinical significance of human leucocyte antigens in transfusion -- Chapter summary -- Further reading -- Discussion questions -- 9.Human Platelet Antigens (HPA) and Human Neutrophil Antigens (HNA) and Their Clinical Significance / Geoff Lucas -- Introduction -- 9.1.Overview of platelet and granulocyte antigens -- 9.2.Human platelet antigens (HPA) -- 9.3.Human neutrophil antigens (HNA) -- 9.4.Antibody detection -- 9.5.Clinical significance of HPA alloantibodies -- 9.6.Clinical significance of HNA antibodies -- Chapter summary --
Further reading -- Discussion questions -- 10.Haemopoietic Stem Cell Banking / Robert Walters -- Introduction -- 10.1.Stem cells -- 10.2.Major histocompatibility complex and human lymphocyte antigens -- 10.3.Sources of haemopoietic stem cells -- 10.4.Stem cell collection and processing -- 10.5.Reinfusion and engraftment -- 10.6.Complications -- 10.7.Health and safety, and statutory requirements -- 10.8.The future of stem cell therapy -- Chapter summary -- Further reading -- 11.Tissue Banking / Richard Lomas -- Introduction -- 11.1.Types of graft -- 11.2.Which tissues are banked and how are they used? -- 11.3.How are donors selected, screened, and consented? -- 11.4.How are tissues retrieved? -- 11.5.Tissue processing and preservation -- 11.6.Storage and distribution -- 11.7.The future---regenerative medicine -- Chapter summary -- Further reading -- 12.Quality Issues / Joan Jones -- Introduction -- 12.1.Evolution of quality --
12.2.Quality management systems -- 12.3.Blood safety and quality regulations -- 12.4.The In Vitro Diagnostic Medical Devices Directive -- 12.5.Clinical laboratory accreditation -- 12.6.The Blood Stocks Management Scheme -- 12.7.Other legislation and regulatory bodies -- 12.8.Guidelines -- 12.9.Haemovigilance -- Chapter summary -- Further reading.
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Holdings
Item type Current library Call number Copy number Status Date due Barcode
Book North Campus North Campus Main Collection 615.39 TRA (Browse shelf(Opens below)) 1 Available A518517B

Includes bibliographical references and index.

1.Introduction to Basic Immunology and Techniques / Robin Knight -- Introduction -- 1.1.Basic immunology and techniques -- 1.2.Antibody structure -- 1.3.Antibody function -- 1.4.Antigen-antibody reactions -- 1.5.Antibody mediated red cell destruction -- 1.6.In vitro detection of antigen-antibody reactions -- 1.7.Techniques -- Chapter summary -- 2.Human Erythrocyte Antigens or Blood Groups / Malcolm Needs -- Introduction -- 2.1.The ABO, H, and Lewis blood group systems -- 2.2.The Lewis blood group system and secretor -- 2.3.The MNS blood group system -- 2.4.The Rh, RHAG, and LW blood group systems -- 2.5.The Lutheran blood group system -- 2.6.The Kell and Kx blood group systems -- 2.7.The Duffy blood group system -- 2.8.The Kidd blood group system -- 2.9.The PIPK blood group system -- 2.10.Other blood groups -- Chapter summary -- Further reading -- 3.Donors and Donation: Collection and Processing / Lionel Mohabir -- Introduction --

3.1.Blood donation -- 3.2.Donor/donation linking -- 3.3.Component preparation -- 3.4.Pathogen reduction -- 3.5.Component validation and labelling -- Chapter summary -- Further reading -- 4.Blood Donation Testing / Lionel Mohabir -- Introduction -- 4.1.Mandatory testing -- 4.2.Additional (discretionary) testing -- 4.3.Microbiology serology testing -- 4.4.Microbiology positive screen and confirmatory testing -- 4.5.Bacterial contamination -- 4.6.West Nile virus (WNV) -- 4.7.Other threats to the blood supply -- 4.8.Quality control/British working standards -- Chapter summary -- Further reading -- 5.Clinical Use of Blood Components / Bill Chaffe -- Introduction -- 5.1.Structure and function of blood -- 5.2.Normal physiological response to anaemia and/or bleeding -- 5.3.Blood components available and their appropriate use -- 5.4.Blood products -- 5.5.Special requirements -- 5.6.Decision making, who needs a transfusion, risks and benefits --

5.7.Alternatives to donor blood -- 5.8.Case history examples -- Chapter summary -- Further reading -- 6.Compatibility Testing and Adverse Effects / Tony Davies -- Introduction -- 6.1.Compatibility testing (serological and non-serological) -- 6.2.Selection of plasma products -- 6.3.Selection of cellular components -- 6.4.Visual inspection and labelling of the units -- 6.5.Traceability of blood components -- 6.6.Adverse effects of transfusion -- 6.7.Monitoring the patient during transfusion -- 6.8.Investigation of transfusion reactions -- 6.9.Haemovigilance in the UK -- Chapter summary -- Further reading -- 7.Immune Red Cell Destruction / Robin Knight -- Introduction -- 7.1.What is immune (antibody mediated) red cell destruction? -- 7.2.Clinical significance of red cell antibodies -- 7.3.Haemolytic transfusion reactions -- 7.4.Autoimmune haemolytic anaemias -- 7.5.Haemolysis post-transplantation bone marrow/stem cell transplant --

7.6.Haemolytic disease of the newborn or foetus (HDN) -- Chapter summary -- Further reading -- 8.Human Leucocyte Antigens and Their Clinical Significance / Colin Brown -- Introduction -- 8.1.A brief history of transplantation -- 8.2.Human leucocyte antigens -- 8.3.The detection and definition of human leucocyte antigens, alleles, and antibodies -- 8.4.Clinical significance of human leucocyte antigens in transplantation -- 8.5.Clinical significance of human leucocyte antigens in transfusion -- Chapter summary -- Further reading -- Discussion questions -- 9.Human Platelet Antigens (HPA) and Human Neutrophil Antigens (HNA) and Their Clinical Significance / Geoff Lucas -- Introduction -- 9.1.Overview of platelet and granulocyte antigens -- 9.2.Human platelet antigens (HPA) -- 9.3.Human neutrophil antigens (HNA) -- 9.4.Antibody detection -- 9.5.Clinical significance of HPA alloantibodies -- 9.6.Clinical significance of HNA antibodies -- Chapter summary --

Further reading -- Discussion questions -- 10.Haemopoietic Stem Cell Banking / Robert Walters -- Introduction -- 10.1.Stem cells -- 10.2.Major histocompatibility complex and human lymphocyte antigens -- 10.3.Sources of haemopoietic stem cells -- 10.4.Stem cell collection and processing -- 10.5.Reinfusion and engraftment -- 10.6.Complications -- 10.7.Health and safety, and statutory requirements -- 10.8.The future of stem cell therapy -- Chapter summary -- Further reading -- 11.Tissue Banking / Richard Lomas -- Introduction -- 11.1.Types of graft -- 11.2.Which tissues are banked and how are they used? -- 11.3.How are donors selected, screened, and consented? -- 11.4.How are tissues retrieved? -- 11.5.Tissue processing and preservation -- 11.6.Storage and distribution -- 11.7.The future---regenerative medicine -- Chapter summary -- Further reading -- 12.Quality Issues / Joan Jones -- Introduction -- 12.1.Evolution of quality --

12.2.Quality management systems -- 12.3.Blood safety and quality regulations -- 12.4.The In Vitro Diagnostic Medical Devices Directive -- 12.5.Clinical laboratory accreditation -- 12.6.The Blood Stocks Management Scheme -- 12.7.Other legislation and regulatory bodies -- 12.8.Guidelines -- 12.9.Haemovigilance -- Chapter summary -- Further reading.

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